{"id":26734,"date":"2024-04-02T13:40:16","date_gmt":"2024-04-02T12:40:16","guid":{"rendered":"https:\/\/opa.org.uk\/?page_id=26734"},"modified":"2024-04-02T13:46:43","modified_gmt":"2024-04-02T12:46:43","slug":"romio-study","status":"publish","type":"page","link":"https:\/\/opa-old.voidappsdev.uk\/?page_id=26734","title":{"rendered":"Romio Study"},"content":{"rendered":"<p><strong>ROMIO is a large randomised controlled trial, which compared open and minimally invasive surgery for oesophageal cancer.<\/strong><\/p>\n<div class=\" sec\">\n<div class=\"title\"><strong>&#8220;Objective<\/strong><\/div>\n<div class=\"title\">This study investigated if hybrid oesophagectomy with minimally invasive gastric mobilization and thoracotomy enabled faster recovery than open surgery.<\/div>\n<\/div>\n<div class=\" sec\">\n<div><\/div>\n<div class=\"title\"><strong>Methods<\/strong><\/div>\n<div class=\"title\">In eight UK centres, this pragmatic RCT recruited patients for oesophagectomy to treat localized cancer. Participants were randomly allocated to hybrid or open surgery, stratified by centre and receipt of neoadjuvant treatment. Large dressings aimed to mask patients to their allocation for six days post-surgery. The authors present the intention-to-treat analysis of outcome measures from the first 3 months post-randomization, including the primary outcome, the patient-reported physical function scale of the EORTC QLQ-C30, and cost-effectiveness. Current Controlled Trials registration: ISRCTN 59036820 (feasibility study), 10386621 (definitive study).<\/div>\n<\/div>\n<div class=\" sec\">\n<div><\/div>\n<div class=\"title\"><strong>Findings<\/strong><\/div>\n<div class=\"title\">There was no evidence of a difference between hybrid (<em>n<\/em>\u00a0= 267) and open (<em>n<\/em>\u00a0= 266) surgery in average physical function over 3 months post-randomization: difference in means 2.1, 95% c.i. \u22122.0 to 6.2,\u00a0<em>P<\/em>\u00a0= 0.3. Complication rates were similar; for example, 88 (34%) participants in the open and 82 (32%) participants in the hybrid surgery groups experienced a pulmonary infection within 30 days. There was no evidence that hybrid surgery was more cost-effective than open surgery at 3 months.<\/div>\n<\/div>\n<div class=\" sec\">\n<div><\/div>\n<div class=\"title\"><strong>Conclusions<\/strong><\/div>\n<div class=\"title\">Patient-reported physical function in the 3 months post-randomization provided no evidence of a difference in recovery time between hybrid and open surgery, or a difference in cost-effectiveness. Both approaches to surgery were completed safely, with a similar risk of key complications, suggesting that surgeons who have a preference for one of the two approaches need not change their practice.&#8221;<\/div>\n<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>\n<div class=\" sec\">\n<div class=\"title\"><\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p>The main paper is published in the British Journal of Surgery: <a href=\"https:\/\/academic.oup.com\/bjs\/article\/111\/3\/znae023\/7634460?login=false\">Laparoscopic or open abdominal surgery with thoracotomy for patients with oesophageal cancer: ROMIO randomized clinical trial | British Journal of Surgery | Oxford Academic (oup.com)<\/a><\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ROMIO is a large randomised controlled trial, which compared open and minimally invasive surgery for oesophageal cancer. &#8220;Objective This study investigated if hybrid oesophagectomy with minimally invasive gastric mobilization and thoracotomy enabled faster recovery than open surgery. Methods In eight UK centres, this pragmatic RCT recruited patients for oesophagectomy to treat localized cancer. Participants were randomly allocated to hybrid or open surgery, stratified by centre and receipt of neoadjuvant treatment. Large dressings aimed to mask patients to their allocation for six days post-surgery. The authors present the intention-to-treat analysis of outcome measures from the first 3 months post-randomization, including the primary outcome, the patient-reported physical function scale of the EORTC QLQ-C30, and cost-effectiveness. Current Controlled Trials registration: ISRCTN 59036820 (feasibility study), 10386621 (definitive study). Findings There was no evidence of a difference between hybrid (n\u00a0= 267) and open (n\u00a0= 266) surgery in average physical function over 3 months post-randomization: difference in means 2.1, 95% c.i. \u22122.0 to 6.2,\u00a0P\u00a0= 0.3. Complication rates were similar; for example, 88 (34%) participants in the open and 82 (32%) participants in the hybrid surgery groups experienced a pulmonary infection within 30 days. There was no evidence that hybrid surgery was more cost-effective than open surgery [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-26734","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Romio Study - The OPA<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Romio Study - The OPA\" \/>\n<meta property=\"og:description\" content=\"ROMIO is a large randomised controlled trial, which compared open and minimally invasive surgery for oesophageal cancer. &#8220;Objective This study investigated if hybrid oesophagectomy with minimally invasive gastric mobilization and thoracotomy enabled faster recovery than open surgery. Methods In eight UK centres, this pragmatic RCT recruited patients for oesophagectomy to treat localized cancer. Participants were randomly allocated to hybrid or open surgery, stratified by centre and receipt of neoadjuvant treatment. Large dressings aimed to mask patients to their allocation for six days post-surgery. The authors present the intention-to-treat analysis of outcome measures from the first 3 months post-randomization, including the primary outcome, the patient-reported physical function scale of the EORTC QLQ-C30, and cost-effectiveness. Current Controlled Trials registration: ISRCTN 59036820 (feasibility study), 10386621 (definitive study). Findings There was no evidence of a difference between hybrid (n\u00a0= 267) and open (n\u00a0= 266) surgery in average physical function over 3 months post-randomization: difference in means 2.1, 95% c.i. \u22122.0 to 6.2,\u00a0P\u00a0= 0.3. Complication rates were similar; for example, 88 (34%) participants in the open and 82 (32%) participants in the hybrid surgery groups experienced a pulmonary infection within 30 days. There was no evidence that hybrid surgery was more cost-effective than open surgery [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/opa-old.voidappsdev.uk\/?page_id=26734\" \/>\n<meta property=\"og:site_name\" content=\"The OPA\" \/>\n<meta property=\"article:modified_time\" content=\"2024-04-02T12:46:43+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/opa-old.voidappsdev.uk\/?page_id=26734\",\"url\":\"https:\/\/opa-old.voidappsdev.uk\/?page_id=26734\",\"name\":\"Romio Study - The OPA\",\"isPartOf\":{\"@id\":\"https:\/\/opa-old.voidappsdev.uk\/#website\"},\"datePublished\":\"2024-04-02T12:40:16+00:00\",\"dateModified\":\"2024-04-02T12:46:43+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/opa-old.voidappsdev.uk\/?page_id=26734#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/opa-old.voidappsdev.uk\/?page_id=26734\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/opa-old.voidappsdev.uk\/?page_id=26734#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/opa-old.voidappsdev.uk\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Romio Study\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/opa-old.voidappsdev.uk\/#website\",\"url\":\"https:\/\/opa-old.voidappsdev.uk\/\",\"name\":\"The OPA\",\"description\":\"Caring for the cancer patient &amp; their family\",\"publisher\":{\"@id\":\"https:\/\/opa-old.voidappsdev.uk\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/opa-old.voidappsdev.uk\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/opa-old.voidappsdev.uk\/#organization\",\"name\":\"The Oesophageal Patients Association\",\"url\":\"https:\/\/opa-old.voidappsdev.uk\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/opa-old.voidappsdev.uk\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/opa.org.uk\/wp-content\/uploads\/2020\/12\/opa-logo-2020-site-icon.png\",\"contentUrl\":\"https:\/\/opa.org.uk\/wp-content\/uploads\/2020\/12\/opa-logo-2020-site-icon.png\",\"width\":512,\"height\":512,\"caption\":\"The Oesophageal Patients Association\"},\"image\":{\"@id\":\"https:\/\/opa-old.voidappsdev.uk\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Romio Study - The OPA","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_GB","og_type":"article","og_title":"Romio Study - The OPA","og_description":"ROMIO is a large randomised controlled trial, which compared open and minimally invasive surgery for oesophageal cancer. &#8220;Objective This study investigated if hybrid oesophagectomy with minimally invasive gastric mobilization and thoracotomy enabled faster recovery than open surgery. 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